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Oporność na wiele leków Polimorfizmy genowe u pacjentów z białaczką malajską

Oporność na wiele leków Polimorfizmy genowe u pacjentów z białaczką malajską

Badrul Hisham Yahaya

75,09 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2021
Materia
Empresa y gestión
ISBN:
9786202735100
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Najczęściej występujące pojedyncze polimorfizmy nukleotydowe (single nucleotide polymorphism - SNP) genu MDR1 (w eksonach 12, 21 i 26) przyczyniły się do powstania oporności na leki w wielu nowotworach. Głównym celem pracy było ustalenie możliwych do zastosowania narzędzi do badania przesiewowego tych trzech najczęstszych polimorfizmów oraz zbadanie rozmieszczenia tych polimorfizmów u chorych na białaczkę malajską. Próbki DNA pobrano od pacjentów z białaczką rozpoznaną jako białaczka poddano analizie dHPLC i RFLP. Z uzyskanych wyników wynika, że u 25 (25,7%) pacjentów stwierdzono mutację heterozygotyczną, u 7 (6,7%) typu wild, a u 2 (1,9%) mutację homozygotyczną. Stwierdzono istotną różnicę w rozmieszczeniu polimorfizmów pomiędzy eksonami 21 i 26 (p

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