Bioinformatics

Bioinformatics is a field of study that integrates biological sciences with computer science. This book is the first of itskind written for students and teachers. It gives the readers an insight into genomics and proteomics including originand history of bioinformatics, computer generations, their types and operating systems, role of PERL and JAVA asprogramming languages, central dogma of molecular biology, with structural details of DNA, RNA, and proteins andfundamental techniques used to study their structures, the database retrieval with PubMed, Entrez, SRS, OMIM,ExPASy, and EMBL, the BLAST and FASTA software packages to determine sequence matches, the computationalmethods for gene prediction, protein sequence databases, Swiss-Prot, PDB, software for visualization of proteinstructure, and the concepts of gene, genome and genomics with the prime role of GenBank, DDBJ, TIGR, KEGGgenomics of bacteriophage to HGP, gene therapy, drug designing and pharmacogenomics. Several web pages withtheir specific URLs are provided that will definitely help readers to interact and learn more about cutting-edgeresearch and visualize complex processes involved in bioinformatics.ContentsIntroductionEvolution of ComputersBiological MacromoleculesBasic Techniques in BioinformaticsBiological DatabasesSequence AlignmentMultiple Sequence AlignmentsComputational Gene PredictionProteomicsGenomics