The Functional Roles of Histamine Receptors

The Functional Roles of Histamine Receptors

 

209,32 €
IVA incluido
Disponible
Editorial:
Springer Nature B.V.
Año de edición:
2022
Materia
Neurología y neurofisiología clínicas
ISBN:
9783031169960
209,32 €
IVA incluido
Disponible
Añadir a favoritos

Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention.Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and its discovery raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs ranging from asthma to cancer. However, several drawbacks emerged and dramatically slowed down research in the field.A better understanding of receptor intra-and interspecies heterogeneity will certainly improve and accelerate the translation of experimental data into clinical practice. Also, the plethora of data on brain histamine is hinting at a fundamental role of this system as a hub that receives internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that preside the appropriate behavioral responses.The development of new histaminergic ligands is an ongoing process that constantly provide new preclinical tools.The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine.

Artículos relacionados

  • Handbook of Research on Innovations in the Diagnosis and Treatment of Dementia
    Ionnis Tarnanas / Leontios Hadjileontiadis / Panagiotis D Bamidis
    Technology is playing an increasing role in the lives of the elderly. One of the most prevalent developments for the aging population is the use of technological innovations for intervention and treatment of individuals with mental impairments. The Handbook of Research on Innovations in the Diagnosis and Treatment of Dementia offers empirical research and theoretical analyses o...
    Disponible

    321,88 €

  • Biomedical Engineering and Cognitive Neuroscience for Healthcare
    Jinglong Wu
    New developments in medical technology have paved the way for the ongoing studies of cognitive neuroscience and biomedical engineering for healthcare. Their different but interconnected aspects of science and technology seek to provide new solutions for difficult healthcare problems and impact the future of the quality of life. Biomedical Engineering and Cognitive Neuroscience ...
    Disponible

    321,66 €

  • Effects of Partial Spinal Cord Injuries on the Functional Connectivity of the Primate Brain
    John Thomas
    The somatosensory system, one of the five main sensory systems in our body enables perception through touch, to help decipher the shape and texture of the objects, and know about the relative position of our body parts. It also helps avoid noxious stimuli by analysing the information about temperature and pain. The system comprises of three major ascending sensory pathways: the...
  • Handbook of Functional MRI Data Analysis
    Jeanette A. Mumford / Russell A. Poldrack / Thomas E. Nichols
    ...
    Disponible

    63,88 €

  • Molecular Mechanisms of Hcy-Induced Neurotoxicity
    Bhavneet Kaur
    'Molecular Mechanisms of Hcy-Induced Neurotoxicity' by Bhavneet Kaur is an in-depth exploration of the molecular mechanisms underlying the neurotoxic effects of homocysteine (Hcy) on the brain. Hcy is an amino acid that is normally found in the body, but at high levels it can be toxic to neurons and contribute to neurological disorders such as Alzheimer’s disease, Parkinson’s d...
  • How Do You Feel?
    A. D. Craig
    A book that fundamentally changes how neuroscientists and psychologists categorize sensations and understand the origins and significance of human feelingsHow Do You Feel? brings together startling evidence from neuroscience, psychology, and psychiatry to present revolutionary new insights into how our brains enable us to experience the range of sensations and mental states kno...
    Disponible

    47,73 €