Megharaja Holiyachi
One of the most important inventions in heterocyclic chemistry is to identify and develop suitable methods in an eco-friendly and sustainable way. Recently, important discoveries were made in regards with L-proline and its derivative catalyzed asymmetric aldol product more efficiently with excellent enantioselectivity using additives. However, these approaches are more useful for avoiding the tedious methods for direct aldol asymmetric synthesis, but still considerable importance for investigation into novel organocatalyst approach. On other hand increasing interest associated with toxicity while modifying catalyst, cost and easily availability also more considerable. Keeping in mind all these disadvantages, water is the best choice as a reaction media and also eco-friendly approach, in this selection unmodified L-proline is an excellent organocatalyst due to tremendous applications including non toxic, hazards free, waste free, inexpensive, non flammable and easy availability. This book will be useful for researchers who are keen to explore the numerous exciting avenues that to investigate efficiency of L-proline and phthalimido-prolinamide for direct asymmetric aldol synthesis.
