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Resposta patológica dos carcinomas da mama após quimioterapia

Resposta patológica dos carcinomas da mama após quimioterapia

Ons Boudaouara / Wiem Ben Makhlouf

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Medicina clínica e interna
ISBN:
9786208954833
65,68 €
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A resposta patológica completa (pCR) no cancro da mama Her-2 positivo é o objetivo final de todos os oncologistas, uma vez que está associada a um melhor prognóstico nestas doentes. Vários autores têm tentado explorar os factores que podem influenciar a qualidade da resposta patológica à quimioterapia neoadjuvante (QNA), numa tentativa de prever a resposta patológica esperada pelo tumor. Neste trabalho, investigámos os fatores potencialmente preditivos de uma pCR e o impacto prognóstico desta última, através de um estudo retrospetivo de 34 doentes com carcinoma da mama Her-2 positivo tratadas por cirurgia após NAC num período de 10 anos, entre 2013 e 2023. Foi obtida uma pCR em 7 doentes (20,6%). Os tumores com estado RH-negativo/subtipo molecular Her-2 sobreexpresso responderam melhor à NAC do que os seus homólogos RH-positivos ou do subtipo molecular Luminal B. Em termos terapêuticos, a adição de Trastuzumab neoadjuvante foi significativamente preditiva de pCR. Ao mesmo tempo, a obtenção de pCR foi associada a um melhor prognóstico.

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