Pancreatic Cancer

Pancreatic cancer is a disease in which cancer cells develop from a glandular organ situated behind the stomach known as pancreas. A thorough comprehension of the biology of pancreatic cancer, heredity, complex signaling pathways as well as alternate therapies has been presented in this book. It elucidates nutrigenomics and epigenetics mechanisms like DNA methylation, which can enable describing the etiology or progression of pancreatic cancer. It also outlines the molecular control of oncogenic pathways like KLF4 and K-Ras. Since this disease metastasizes to essential organs resulting in poor prognosis, particular stress has been laid on the mechanism of tumor cell metastasis and invasion. Detailed information regarding the role of Syk kinase and nitric oxide in tumor metastasis has also been presented. Preventive techniques against this disease have also been highlighted. The molecular mechanisms of the anti-cancer impacts of benzyl isothiocynate, vitamin D and curcumin have also been described comprehensively in this extensive book. It also encompasses the fundamental mechanisms of resistance against this disease and chemotherapy drugs like 5-fluorouracil and gemcitabine. This book will be a valuable account of information to the readers. 3