La méningite carcinomateuse d’origine mammaire

La méningite carcinomateuse d’origine mammaire

Ons Boudaouara

64,18 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
ISBN:
9786208822224
64,18 €
IVA incluido
Disponible
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La méningite carcinomateuse (MC), constitue un évènement rare et tardif, compliquant environ 5 à 8% des cancers mammaires. A ce stade, la médiane de survie des patients chute dramatiquement et dépasse rarement les 6 mois. Ces résultats décevants ont incité certains auteurs à investiguer les facteurs pouvant influencer le pronostic des patients, et ce dans une tentative de stratification pronostique et d’adaptation des protocoles thérapeutiques. Dans cette étude, nous avons étudié l’impact pronostique de certains facteurs clinico-pathologiques et thérapeutiques dans une étude rétrospective de 20 patients atteints de MC d’origine mammaire sur une période de 16 ans entre 2005 et 2021. Un décès imputable à la maladie a été noté dans 19 cas avec une médiane de survie globale estimée à 5 mois. Les résultats de notre étude affirment la valeur pronostique positive d’un statut de performance élevé au moment du diagnostic de la MC et de l’administration d’un traitement systémique adéquat. L’impact pronostique péjoratif de la présence de métastases cérébrales et de l’utilisation d’une seule modalité thérapeutique a été vérifié en analyse unie et multivariée.

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