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Formulation et évaluation de vésicules furtives chargées de didanosine

Formulation et évaluation de vésicules furtives chargées de didanosine

Kolapalli Venkata Ramana Murthy / Sudhakar Beeravelli / Swathi Polipilli

74,22 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Farmacología
ISBN:
9786202701976
74,22 €
IVA incluido
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Les systèmes vésiculaires sont de nouveaux moyens d’administrer des médicaments de manière contrôlée afin d’améliorer la biodisponibilité et d’obtenir un effet thérapeutique sur une période de temps plus longue. Les vésicules sont des particules colloïdales dans lesquelles une bicouche concentrique composée de molécules amphiphiles entoure un compartiment aqueux. Elles constituent un moyen utile de véhiculer ou d’administrer des médicaments hydrophobes, qui sont associés à la bicouche lipidique, et des médicaments hydrophiles, qui sont encapsulés dans le compartiment aqueux intérieur. En général, les vésicules composées de phospholipides naturels ou synthétiques sont appelées liposomes, tandis que celles composées de tensioactifs non ioniques (par exemple, des alkythers et des alkylesters) et de cholestérol constituent un système vésiculaire de tensioactifs non ioniques appelé niosomes. Les vésicules sont généralement classées en deux catégories : les vésicules classiques et les vésicules à longue circulation (VLC). Le terme de vésicule classique (CV) a été utilisé en raison de la pharmacocinétique dépendante de la dose et de la courte circulation des demi-vies, en particulier après l’administration intraveineuse de faibles doses.

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