This reprint compiles cutting-edge research and insights from the Special Issue 'Fire/Explosion Risk Assessment and Loss Prevention of Hazardous Materials, Mines, and Natural Gas.' It addresses critical challenges in managing and mitigating risks associated with hazardous materials, mining operations, and natural gas infrastructures. The contributions explore innovative methodologies, advanced technologies, and best practices for risk assessment, safety management, and loss prevention. By integrating multidisciplinary perspectives, this reprint serves as a valuable resource for researchers, industry professionals, and policymakers aiming to enhance safety standards and reduce the potential for catastrophic incidents. The findings and recommendations presented here are particularly relevant in the context of increasing industrial complexity and the growing demand for sustainable and safe energy solutions. This reprint underscores the importance of proactive risk management and offers actionable insights to safeguard lives, assets, and the environment.