K. Purushottam Rao / Nadeem Hasan / Sanaullah Syed
In the present work, it was planned to prepare therapeutic medicated dental pastes for treatment of periodontitis (dental inflammation) and pain which provide effect for extended period of time. Stress was given for local action of the drug and improve mucoadhesive characteristics of the prepared formulations by adding required amount of mucoadhesive polymers. Diclofenac sodium and nimesulide was chosen as an analgesic and anti-inflammatory drug due to safety, low toxicity and high efficacy. Pastes were comprising of stabilizer mucoretention/ muco-adhesive polymers such as methyl cellulose, hydroxy ethyl cellulose and carboxymethyl cellulose sodium and subjected for various physicochemical parameters like pH, spreadability, extrudability, drug content, viscosity, mucoadhesive study and IR studies. In vitro drug release studies carried out in phosphate buffer pH 6.4. Stability studies were also done at temperature 45±2ºC and 5ºC. During physicochemical studies significant results were obtained and the in vitro drug release in pastes were found to exhibit extended release and good adhesion to the oral mucosa revealing more retention time in mouth.
